Laser Ablation Tomography (LATscan) is capable of rapidly acquiring 3D structural and compositional data with nanometer resolution in opaque specimens. The LATscan 16, 30, and 45 (capable of higher) watt nanosecond pulsed laser and a rapidly-swept galvanometer scanner to continuously vaporize a thin surface layer of a sample. The emitted light is directed through an optical system for filtering and imaging, creating highly contrasted, colorful stacks of images. Stacks of images are then processed and reconstructed into a high-resolution volume rendering that can be analyzed, quantified, segmented and virtually dissected.
Although dependent on sample size and composition, acquisition speeds exceed that of conventional techniques like micro x-ray CT and confocal microscopy. This method allows for data acquisition at unprecedented speed with little to no need for staining or complex preparatory procedures, facilitating more rapid scientific discovery. 3D analysis technologies that are simple, quantitative and rapid have greatly assisted in the understanding of scientific research and development. The ability to visually screen and perform morphometric analysis of organic matter and of materials is an indispensable tool in the quest to find unique, advantageous traits and insight into complex regulatory pathways. Laser Ablation Tomography was developed to facilitate these discoveries.
SERVICING ANY INDUSTRY
Our team of experts have worked on countless projects of all shapes and sizes, from roots to seeds, insects to mice, batteries to denim. We have developed a unique method for data optimization and validation for specimens, and coupled with our expertise of high content imaging, we can quantify nearly any target. We are experts in agriculture and have worked with many different animals and materials. We have working closely with Bayer Monsanto and universities from around the world to provide only the best data analysis and 3D modeling.
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We service any industry and we routinely develop custom projects on our clients’ proprietary targets. All we need is to know what you are specifically looking to research. We keep your all research confidential.
3D MODEL RENDERING​​
LATscan is a highly sought after contract research organization offering a combination of our expertise in 3D organic and material models and our suite of 3D imaging and machine learning tools. The average project turnaround is less than two weeks, including generation of the model, labeling, imaging, and data analysis. We provide a comprehensive report summarizing findings as well as all raw data generated throughout the project.
VIDEO OF MAIZE ROOT
VIDEO OF HUMMING BIRD
VIDEO OF DENIM FABRIC
VIDEO OF SOIL
QUANTITATIVE DATA ANALYSIS
Latscan technology can easily produce hundred of thousands of images. Though this may seem like a major bottleneck for processing and analyzing data. Our process will take 7 images a second from ablation to image construction. We can accomplish a 1mm long section is 140 seconds with your choice of image slicing distance ranging from 1 micron or higher. We quickly parse through hundreds of thousands of images to obtain quantitative data, extracting structural dimensions, computational fluid dynamics, segmentation, and computing statistical comparisons between samples. This data can be exported to CAD and structural models with analysis. We preform the heavy lifting of organizing gigabytes to terabytes of data to structure your data to your specifications, delivering finalized reports that allow you to make new and accurate decisions, all the while of acting quickly.
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We work closely and diligently with our clients to define the exact needs of your project. We offer small-scale proof-of-concept work to demonstrate our expertise and build your confidence that your projects will be in good hands.
Comparison between LATscan and X-Ray Microtomography
THE RESULTS
Analysis of sample performed on GE Nanotome (right picture in both images) took approx 2 hours acquisition time. The sample dried out during analysis. LATscan (left picture in both images) of fresh sample, for reference, took approximately 40 second for data acquisition time. The sample did not dry out during analysis.
LATSCAN BENEFITS
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Zero or minimal sample preparation
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Rapid data acquisition of biological samples - 1mm long section in 140 seconds
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Sample size up to one inch by one inch
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Full color
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High resolution (not dependent on sample dimensions) - 400 nanometers and greater
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Enables virtual analysis of internal and external structure
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Data mining using machine learning facilitate rapid feature recognition and quantification
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Easily integrated into existing sample analysis pipelines
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Analysis is material indifferent
